Wartime research on nitrogen mustard
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چکیده
منابع مشابه
Evidence for a Transport Carrier of Nitrogen Mustard in Nitrogen Mustard-sensitive and -resistant L5178Y Lymphoblasts1
inhibited by ouabain and 2,4-dinitrophenol. These findings suggest that transport of HN2 is carrier-mediated and is an active process. The Km for resistant cells was higher than that of sensitive cells, suggesting a decreased affinity of the trans port carrier for drug. The Vmax of resistant cells was lower than that of sensitive lymphoblasts, suggesting decreased trans port capacity in resista...
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During World War II, behavioral scientists working for several U.S. agencies—principally the Office of Strategic Services, but also the Office of War Information, the Strategic Bombing Survey, and military authorities—advanced personality and social psychology through their investigations of the nature of Nazism, Adolf Hitler's personality, the German national character, and Germans' reactions ...
متن کاملEffects of Endotoxin and Nitrogen Mustard on Leukocyte Kinetics.
By JOHN C. HERION, RICHARD I. WALKER,#{176} WILLIAM B. HERRING AND JEFFRESS G. PALMER B ACTERIAL ENDOTOXINS have been shown to affect granulocytes in a variety of ways.13 When injected intravenously, these substances produce a decrease Ill circulating lymphocytes and granulocytes, followed by leukocytosis due exclusively to an increase in granulocytes.24 Large doses of endotoxin, however, may d...
متن کاملHematologic effects of regional nitrogen mustard therapy.
By JEANNE C. BATEMAN,* M.D., CALVIN T. KLOPP, M.D., and J. KEITH CROMER, M.D. M ETHYL his (beta-chloroethyl) amine hydrochloride (referred to hereafter as HN2) has been established as an effective agent in the palliative therapy of certain malignant diseases, includ!ing Hodgkin’s dhsease, lymphosarcoma, mycosis fungoides, chronic leukemia, polycythemia and some cases of inoperable carcinoma of ...
متن کاملTreatment of bronchogenic carcinoma with nitrogen mustard.
There have been numerous reports as to the clinical results obtained with the chloroethylamines (nitrogen mustards) In the treatment of Hodgkin’s disease, lymphosarcoma and leukemia.’-11’9 There has been a paucity of reported clinical trials in regard to the treatment of bronchogenic carcinoma with nitrogen mustard despite the fact that a few cases of carcinoma of the lung treated with nitrogen...
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ژورنال
عنوان ژورنال: Nature
سال: 1979
ISSN: 0028-0836,1476-4687
DOI: 10.1038/282128d0